综上所述，目前成功的糖尿病治疗策略重点应该从单纯的控制血糖转换为以修复受损的β细胞功能上来；无论是体内和体外的研究中， TZDs都可以减轻胰岛β细胞的负荷，降低高糖、高脂的毒性，下调炎症和免疫反应，减少胰岛β细胞的凋亡，已初步显示了改善胰岛β细胞的功能。然而，如何彻底的阻断这一过程还有待近一步研究。如果TZDs确实能够阻断胰岛β细胞功能减退的病程，那么将会掀起糖尿病预防和治疗的新篇章，我们期待着这一天的到来。

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